Although there is no known animal model for human disease large animal models have demonstrated better suitability for translation to humans for instance swine a species that spontaneously develops atherosclerosis and thrombosis are more closely mimics of the macrovascular related thrombotic complications found in humans. Atherosclerosis is a chronic inflammatory disease that is an underlying basis for most cardiovascular diseases in humans animal models are indispensable for studying the molecular mechanisms that promote atherogenesis and testing therapeutic strategies both large and small animal models have been used to study atherogenesis. The use of animals as experimental models for human diseases is currently seen as an imperative in understanding the causes biology and prevention of diseases animal models over the years have been used extensively in biomedical field since the early 1980s 1 . A 2013 article in the proceedings of the national academy of sciences pnas concerning the use of murine models to study human inflammatory disease spawned debate across multiple scientific disciplines 1 the title of this article was genomic responses in mouse models poorly mimic human inflammatory diseases
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