Cirrhosis also can be complicated by the development of hcc which may worsen portal hypertension deplete parenchymal reserves and result in catastrophic complications. Icomplications of chronic liver disease raymond t chung md david l jaffe md and lawrence s friedman md any chronic disease of the liver may result in cirrhosis a process in which diffuse destruction and regeneration of hepatic parenchymal cells lead to deposition of connective tissue with resulting disorganization of the lobular and vascular architecture. Complications of chronic liver disease and treatment of chronic hepatitis c an update introduction the 66 th annual scientific meeting of the american college of gastroenterology included a chronic hepatitis c patients with early chronic hepatitis c virus hcv infection typically remain . Liver disease doesnt always cause noticeable signs and symptoms if signs and symptoms of liver disease do occur the may include skin and eyes that appear yellowish jaundice abdominal pain and swelling swelling in the legs and ankles itchy skin dark urine color pale stool color chronic fatigue nausea or vomiting loss of appetite tendency to bruise easily